Expression and clinical significance of Bcl-2 in gastric carcinoma

VernacularTitle:Bcl-2在胃癌中的表达及其临床意义
Author: Lei REN ; Yejiang ZHOU ; Chunfeng LIU
Publication Type:Journal Article
Keywords: Lymphoma,B-cell; Stomach neoplasms; Carcinoma; Apoptosis
From: International Journal of Surgery 2013;(3):164-166,封3
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of B-cell lymphoma/leukemia-2 gene (Bcl-2) in the gastric carcinoma,and the relationship between Bcl-2 and clinical biological behaviour and prognosis.Methods To use SP immunohistochemistry to detect respectively the expression level of Bcl-2 in the gastric carcinoma and incisal margin epithelial tissue of 42 gastric carcinoma patients.Results The positive expression rates of Bcl-2 in the gastric carcinoma and incisal margin epithelial tissue were 69.05％ and 21.43％.It had statistical significance (P ＜0.05) ; the expression of Bcl-2 in gastric carcinoma had not significantly correlation repectively with patient' s age,gender and invasive depth (P ＞ 0.05),but had significantly correlation with differentiation,TNM stage and lymph node metastasis of the tumor (P ＜ 0.05).Conclusion The expression level of Bcl-2 in gastric carcinoma may be one of biology indexes of the inwsion,migration,advancement and prognosis of the gastric carcinoma.