Polymorphisms of GSTM1,GSTT1 and susceptibility of laryngeal and hypopharyngeal carcinomas
10.3969/j.issn.1001-1781.2009.24.001
- VernacularTitle:谷胱苷肽S转移酶M1和T1基因多态性与喉及下咽癌易感性
- Author:
Qin LI
;
Lingrong WANG
;
Yanlin CHEN
;
Yinghua DU
;
Ping KONG
;
Yufen LI
;
Xiaoqun XU
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasms;
hypopharyngeal neoplasms;
glutathione s-transferase;
geneticpolymorphism;
susceptibility;
smoking
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(24):1105-1107,1111
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between genetic polymorphisms of GSTM1 GSTT1 and the susceptibility of laryngeal and hypopharyngeal carcinomas(LHC).Method:The GSTM1 an GSTT1 genotypes were determined by multiplex PCR analysis in 76 LHC patients and 76 population controls.The association be tween the genotypes and LHC risk was measured by odds ratios(ORs)and 95% confidence intervals(95%Cls).Resuit:The frequency of GSTM1 null genotype was 59.2% in the LHC patients and 42.1% in controls(OR=1.935,95%CI=1.069-3.510),the difference was significant(P＜0.01).The frequency of GSTT1 null genotype was 57.9% in the LHC patients and 51.3% in controls.The difference was not significant(P＞0.05).In smokers,the risk of the LHC increased in subjects of GSTM1 null genotype(OR=5.545,95%CI=2.158-13.528).Conclusion:GSTM1 polymorphisms are associated with susceptibility to the LHC.It has the synergistic effects with smoking in the development of the LHC.GSTT1 genotypes might have no association with risk of the LHC in urban Linyi.
