Significance of renal interstitial foam cells in patients with glomerular disease
10.3969/j.issn.1001-7399.2009.06.010
- VernacularTitle:肾小球疾病间质泡沫细胞的分布及其临床病理意义
- Author:
Hua SU
;
Ling FU
;
Hongyan ZHU
;
Anguo DENG
- Publication Type:Journal Article
- Keywords:
foam cells;
glomerular sclerosis;
interstitial fibrosis
- From:
Chinese Journal of Clinical and Experimental Pathology
2009;(6):606-609,614
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To observe the pathologic types of glomerular diseases which have high renal interstitial foam cells infiltration and to evaluate the relationship between infiltration of foam cells (FC) in renal interstitial tissue and pathologic parameters.Methods A total of 2 862 patients who had received renal biopsy were enrolled in this study. Patients with Alport syndrome (AS,n=5), membranous proliferative glomerular nephritis (MPGN,n=28), focal segmental glomerulosclerosis (FSGS,n=144), idiopathic membranous nephropathy (IMN,n=132), IgA nephropathy (IgAN,n=893) were divided into two groups:FC+ group with foam cells and FC- group without foam cells.Results Infiltration of foam cells in renal interstitial tissue was commonly seen in AS.The frequency of interstitial foam cells was 46.43% in MPGN, 20.14% in FSGS, 13.64% in IMN, and 6.27% in IgAN. It was found that the segmental glomerular sclerosis and interstitial fibrosis were more severe in FC+ group than that in FC- group.Conclusions The renal interstitial foam cells are most common in patients with AS, but also seen in patients with MPGN, FSGS, IMN and IgAN. There might be a relationship between glomerular sclerosis, interstitial fibrosis and infiltration of foam cells. The present of foam cells in the renal interstitial tissue may contribute to the progression of renal diseases.
