To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm by immunohistochemistry
10.3969/j.issn.1001-1781.2009.21.007
- VernacularTitle:喉癌组织中Stat3及其靶基因Cyclin D1蛋白的表达及其相关性研究
- Author:
Hongjun LIANG
;
Bin LIU
;
Wenyue JI
- Publication Type:Journal Article
- Keywords:
laryngeal neoplasm;
immunohistochemistry;
Stat3;
Cyclin D1
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2009;(21):982-984,988
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method.Method:With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinical pathological factor.Result:Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship.Conclusion:Active Stat3 may promote the transcription of target gene Cyclin D1,which could accelerate carcinomatous change.
