The Treatment of Chronic Atrophic Gastritis with Dysplasia by Chinese Medicine:A Systematic Review
- VernacularTitle:中医药治疗慢性萎缩性胃炎伴异型增生疗效的系统评价
- Author:
Xia WEI
;
Danping QIN
- Publication Type:Journal Article
- Keywords:
chronic atrophic gastritis;
dysplasia;
traditional Chinese medicine;
cure effect;
meta-analysis
- From:
Journal of Zhejiang Chinese Medical University
2013;(7):864-868,869
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] Through a meta-analysis to compare the effectiveness and safety of traditional Chinese medicine and western medicine in the treat-ment of chronic atrophic gastritis(CAG) with dysplasia . [Methods] Randomized clinical trials(RCTs) which compared traditional Chinese medicine and western medicine for chronic atrophic gastritis with dysplasia in PubMed, Cochrane library, WanFang and CNKI were searched. The patients which were analyzed were divided into two groups: western medicine and traditional Chinese medicine.Statistical heterogeneity between trials was evaluated by RevMan5.0. Heterogeneity of the included articles was tested and used to select proper effective model for calculation.Publication bias was investigated through visual inspection of funnel plots and Egger's regression model.[Results] 6 RCTs including 632 patients were analyzed. The total odd ratios(OR) of clinical symptoms,gastroscope symptoms,pathological symptoms by traditional Chinese medicine were higher than western medicine, the OR values were 3.40(95%CI:2.18~5.31,P<0.01),4.14(95%CI:2.37~7.20,P<0.01),2.94(95%CI:1.77~4.90,P<0.01),3.71(95%CI:2.29~6.02,P<0.01),4.41(95%CI:2.75~7.07,P<0.01),5.21 (95%CI:3.65~7.43,P<0.01). Inspection of the funnel plots for al outcome measures did not reveal evidence of publication bias( P=0.81, 0.41, 0.29, 0.88, 0.44, 0.82, respectively).[Conclusions] The treatment of chronic atrophic gastritis with dysplasia by traditional Chinese medicine can improve the excel ent response rate, overal response rate of clinical symptoms,gastroscope symptoms,pathological symptoms better than its purely western medicine treatment efficacy.
