The study of the expression of E-cadherin and Snail in the labial glands of the patients with primary Sj(o)gren's syndrome
10.3760/cma.j.issn.1007-7480.2013.07.004
- VernacularTitle:上皮型钙黏附蛋白和Snail在原发性干燥综合征患者唇腺组织中表达的相关研究
- Author:
Xiqian HOU
;
Hong ZHU
- Publication Type:Journal Article
- Keywords:
Sj(o)gren syndrome;
Salivary gland diseases;
Immunohistochemistry
- From:
Chinese Journal of Rheumatology
2013;(7):443-445,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of E-cadherin protein and Snail protein in the labial glands of patients with primary Sj(o)gren's syndrome(pSS) and to analyze their roles in the pathogenesis of pSS.Methods The expression of E-cadherin protein and Snail protein were detected by immunohistochemical method.The labial glands were obtained from 50 patients with pSS and 30 healthy controls.The data was analyzed by Chi-Square test,Fisher's exact probability and Spearman's rank correlation analysis.Results The expression rate of E-cadherin in the labials gland of the patients with pSS were lower than that in normal salivary tissues (x2=14.651,P＜0.01).The positive rates of Snail in the labial glands of the patients with PSS were 40％ and it's expression rates were significantly higher than those in normal salivary tissues (x2=28.800,P＜0.01).There was a negative correlation between lymphocyte focus score and the expression of E-cadherin (P＜0.01) and a positive correlation between lymphocyte focus score and the expression of Snail in pSS group (P＜0.01).There was a negative correlation between the expression of E-cadherin and Snail (rs=-0.484,P＜0.01).Conclusion The interaction of E-cadherin and Snail may have played an important role in the pathogenesis of PSS.
