Advances of epigenetic mechanism of congenital heart disease
10.3760/cma.j.issn.1673-4408.2013.03.010
- VernacularTitle:先天性心脏病表观遗传机制研究进展
- Author:
Luanluan LI
;
Huafei ZHOU
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
Epigenetics;
DNA methylation;
Histone modification;
Chromatin remodeling;
Non-coding RNA regulation
- From:
International Journal of Pediatrics
2013;(3):247-249,253
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetics refers to the heritable changes in gene expression without an alteration in the DNA sequence of the genome.Epigenetic mechanism involves DNA methylation,histone modification,chromatin remodeling,non-coding RNA regulation and so on.Many experimental investigations indicate that the abnormalities in epigenetic regulation during cardiac development may be responsible for the progression of congenital cardiac disease.Based on the four aspects of epigenetic regulation above,this review mainly discusses the advances of epigenetic mechanism of congenital heart disease.
