Analysis on the risk factors of radiation pneumonitis in lung cancer patients
10.3760/cma.j.issn.1006-9801.2013.05.016
- VernacularTitle:肺癌患者放射性肺炎相关因素分析
- Author:
Xiurong QI
;
Shuping ZHANG
;
Zhongren ZHAO
;
Lei LI
;
Shumin CUI
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Radiotherapy,computer-assisted;
Pulmonary disease,chronic obstructive;
Dose volume histogram
- From:
Cancer Research and Clinic
2013;(5):336-338,341
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relative factors of radiation pneumonia(RP) in patients with lung cancer after radiotherapy,and find predictors of reasonable.Methods 98 cases received radical radiotherapy of non-small cell lung cancer patients were included,prescription dose of 60-68 Gy,clinical symptoms,chest X-ray,HRCT were used to detect RP.The clinical factors and treatment parameters were collected.Analysis of univariate and multivariate were used for chnical data and treatment planning indicators,assessment of RP related factors.Results 26 cases (26.53 ％) were RP in 2 above (≥2).The univariate anaiysis revealed that many parameteers (chronic obstructive pulmonary disease,whether chemotherapy,tumor volume,V20,V25,V30) were significantly associated with RP (x2 =12.253,x2 =8.802,t =3.758,t =3.432,t =3.210,t =3.190,P ＜ 0.05).Multivariate analysis revealed that COPD and V20＞25 ％,V30＞18 ％ were associated with RP (x2 =4.17,24.18,3.56,P =0.045,0.041,0.000).Conclusion Lung V20,V30,patients with chronic lung disease are the independence of the influencing factors of RP.In patients with chronic obstructive pulmonary disease the dose of normal tissue should be strictly controled,V20 ≤ 25 ％,V30 ≤ 18 ％.
