The preparation of inclusion compound of diclofenac sodium-β-cyclodextrin
- VernacularTitle:双氯芬酸钠-β-环糊精包合物的研制
- Author:
Fugen GU
;
Cuijing LIU
- Publication Type:Journal Article
- Keywords:
diclofenac sodium;
β-cyclodextrin;
inclusion compound;
gastric irritation
- From:
Chinese Pharmaceutical Journal
1998;(3):153-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To prepare the inclusion compound of diclofenac sodium (DFS)-β-cyclodextrin (β-CD) and investigate its properties. METHOD: The inclusion compound of DFS-β-CD was prepared by the co-precipitation method. RESULTS: The inclusion compound of DFS-β-CD was confirmed by UV absorption spectrum, IR absorption spectroscopy, differential scanning calorimetry (DSC) and phase solubility diagram. Meanwhile, the content analysis of the inclusion compound showed that the molecular ratio of DFS to β-CD was 1∶1. CONCLUSION: The soluability and dissolution rate of DFS were increased and its irritation to stomach was reduced when the drug was included by β-CD.
