Study on the inclusion actions of diclofenac sodium and β-cyclodextinr in aqueous solution
- VernacularTitle:双氯芬酸钠和β-环糊精在水溶液中的包合作用
- Author:
Yanbing ZHANG
;
Xuefen WU
;
Qingzhi ZHAO
- Publication Type:Journal Article
- Keywords:
diclofenac sodium;
cyclodextrins;
inclusion ratio;
solubility;
ultraviolet speetra
- From:
Chinese Pharmaceutical Journal
1999;(3):165-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：Probe into the feasibility of preparation of diclofenac sodium with β-cyclodextrins in 1∶1 and 2∶1 inclusion compounds ,and find out the affection in solubility of diclofenac sodium. METHODS:The 1∶1 and 2∶1 melusion compounds were prepared by liquid-phase an alysis the content and determination them solubility.RESULT:The 1 ∶1 and 2∶1 inclusion compounds were prepared by different ratio of reactants and etermined them mp were 299～300.5℃ and 302～303℃ respectively. CONCLUSION：Of us is that solubilits of the 1∶1 and 2∶1 inclusion compounds increase 0.65 and 1 times respetively comparing with declofenac sodium.
