Pharmacokinetics of netilmicin in patients with burns
- VernacularTitle:奈替米星在烧伤患者体内药代动力学研究
- Author:
Jiancun ZHEN
;
Shiri CUI
- Publication Type:Journal Article
- Keywords:
netilmicin;
pharmacokinetic;
burn;
exudate
- From:
Chinese Pharmaceutical Journal
1999;(3):174-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE：To determine the pharmacokinetic parameters and- concentrations of netilmicin in the blood,exudate and urine in 10patients with burns.METHOD:The pharmacokinetic parameters and concentrations of Netilmicin in the blood,urine and exudate were determined by FPIA.Netilmicin was given at a single-dose of 6mg.kg-1 by intravenous infusion.RESULTS:The main pharmacokinetic parameters were t1/2=(240.28±109.98) mins,Cls=(0.0973±0.0198)mg.min-1.μg-1.ml-1.The mean blood concentration was (1.56±0.66)μg.ml-1 at 8h after administration.The elimination rates of netilmicin in urine were (73.36±10.04)% and (83.39±9.46)% after 12 h and 24 h respectively. CONCLUSION:Netilmicin(6mg.kg-1)can contre the burn infetion,but the pharmacokinetic parameters are varied in different individuals,the blood concentration must be monitored.
