Preparation of carboplatin-loaded albumin microsphere and its properties in vitro
- VernacularTitle:卡铂白蛋白微球的制备和体外性质
- Author:
Hao ZHU
;
Xuetao JIANG
;
Fenghua XU
- Publication Type:Journal Article
- Keywords:
carboplatin;
albumin microsphere
- From:
Chinese Pharmaceutical Journal
1998;(2):91-
- CountryChina
- Language:Chinese
-
Abstract:
To prepare bio-degradable albumin microspheres containing carboplatin. METHODS: Bovin serum albumin microspheres containing carboplatin were prepared by using emulsion-direct heat cross linking techniques. RESULTS: The microsphere was yellow, powdery, with a mean diameter of 58.2 μm. The microphere loaded (11.26±0.48)% carboplatin. The trapping efficiency was (84.5±3.6)%. The pattern of drug releasing from the microspheres in vitro fitted to zero order release plot, with an initial burst in the first 2 hours. The releasing rate can be expressed by the follow equation: Q=21.90+8.50 t (d), r=0.995 8. t50=3 d. Stored at 4 ℃ and 37 ℃ respectively for 3 months, the microspheres did not alter much in shape, size and drug content. CONCLUSIONS: This method is simple, reproducible, having high drug trapping efficiency. The microsphere obtained is stable and release drug at a consistant rate in vitro, leading to a prosperity in clinical use.
