Enhanced percutaneous penetration with borneol
- VernacularTitle:龙脑促进药物经皮渗透作用的研究
- Author:
Jianping ZHU
;
Zongrui WANG
;
Songxia WU
- Publication Type:Journal Article
- Keywords:
borneol;
Azone;
percutaneous penetration enhancer
- From:
Chinese Pharmaceutical Journal
1999;(2):104-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of borneol affecting the transdermal amount of drugs.METHODS:Drugs permeation tests were performed in a two-compartment diffusion cell through cobra skin in vitro,in rabbits and on the human skin blanching assay in vivo,respetively.RESULTS:In vitro,borneol increased the percutaneous transport of metronidazole and 5-fluorouracil.The potency of 3.0% borneol was different from that of 1.0%borneol.On the human skin beanching assay in vivo it indicated that borneol enhanced the bioavailability of percutaneous penetration of triamcinolone acetonide acetate.In rabbits,borneol increased AUCo～12h of salicylic acid in plasma.CONCLUSION:It indicated borneol is a effective percutaneous penetration enhancer.
