The comparision of in vitro antibacterial activities of two drugs for ophthalmia neonatorum prophylaxis
- VernacularTitle:两种预防新生儿眼炎药物的体外抗菌活性比较
- Author:
Cai LIN
;
Dong LUO
;
Lühua ZHONG
- Publication Type:Journal Article
- Keywords:
ophthalmia neonatorum;
in vitro antibacterial activity;
povidone-iodine;
silver nitrate
- From:
Chinese Pharmaceutical Journal
1999;(2):111-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To eualuate in vitro antibacterial activities of silver nitrate and povidone-iodine for preventing ophthalmia neonatorum. METHODS:Minimal inhibitory concentration(MIC) and mininmal bactericidal concentration (MBC) were deter-mined by double broth dilution method. RESULTS:For Stapanrens Streppnenmonia and N gonorhveae,the MIC50 of silver nitrate were＜4～8μg.ml－1 and its MIC90 were 8～32μg.ml－1.The MIC50 of povidone-iodine were64～256μg.ml－1 and its MBC90were 512 μg.ml-1. CONCLUSION: Silver nitrate and povidone-iodine exhibited activities against common pathogens of ophthalmia neonatorum isolates.Silver nitrate was more active than povidone-iodine.
