Effect of Erigeron Injection on Biochemical Indicators of Hepatotoxicity in Mice
10.3870/j.issn.1004-0781.2001.05.006
- VernacularTitle:灯盏花注射液对小鼠肝损伤生化指标的影响
- Author:
Zhang ZHUAN
;
Xiao JUN
;
Wang HUI
- Publication Type:Journal Article
- From:
Herald of Medicine
2001;(5):286-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effects of erigeron injection on the biochemical indicators of hepatotoxicity caused by ischemia and reperfusion of the mice intestine. Methods:A experimental model of liver lesion induced by ischemia－reperfusion of the mice intestine was set up. Serum was obtained after 20 minutes of ischemia followed by 1 hour of reperfusion. Contents of SOD and MDA in liver were measured. Results: The serum ALT significantly increased following ischemia and reperfusion, which was attenuated by the erigeron injection (P＜0.01). Erigeron injection can also increase the contents of SOD and MDA in the mice liver (p＜0.05 and 0.01, respectively). Conclusion: Erigeron injection can improve the biochemical indicators of liver lesion induced by ischemia and reperfusion of the mice intestine. It is indicated that the protective effects of erigeron injection was related to anti－oxidation mechanisms.
