STUDIES ON IMMUNOPROPHYLAXIS OF SWINE CYSTICERCOSIS WITH THE ANIMAL MODEL OF KUNMING MOUSE
10.3969/j.issn.1002-2694.2000.06.019
- VernacularTitle:应用小鼠动物模型进行猪囊虫病免疫预防的实验研究
- Author:
Yude TANG
;
Zhixing GU
;
Yu LIU
;
Xingming YU
- Publication Type:Journal Article
- Keywords:
Swine cysticercosis;
animal model;
vaccination;
the genetic engineering vaccine
- From:
Chinese Journal of Zoonoses
2000;(6):56-57,60
- CountryChina
- Language:Chinese
-
Abstract:
AimTo investigate the immune effects of the genetic engineering vaccine against swine cysticercosis with the animal mode of kunming mouse. Method78 kunming mice were randomly divided into three groups: 1 )injection one times with the vaccine, 2)injection twice with the vaccine at intervals of ten days, 3)non-vaccination group. All the mice were infected with the vial hatched oncopheres by the tag vein at 20 days after the first vaccination,and were killed and dissected to look for swine cysticerci 63 days later. In order to know the immune response of the vaccine and the stateof parasites in the rats,the antigens and antibodies of swine cysticerci were detected by immune methods. ResultsThe vaccine was safety to all the vaccinated rats. The antibodies against swine cysticerci began to appear positive in some of the immunized mice at 7 days postvaccination,and they were all positive at 21 days. 65 cysticerci were found in the mice of the nonvaccination group,which lodged mainly in the chests. 2 and lcysticerci were respectively found in two rats of the first group and in one rat of the second group, their protective rates of cysticerci were 96.9％ and 98. 4％,respectively. ConclusionKunming mouse as the animal model of swine cysticercosis was stable and reliable,and the genetic engineering vaccine against swine cysticercosis was safety and efficiency.
