Clinical significance of SKP2 and MRP-1/CD9 expression in glottic carcinoma and adjacent tissues
10.3969/j.issn.1001-1781.2010.04.006
- VernacularTitle:SKP2及MRP-1/CD9在声门癌及癌旁组织中的表达及其临床意义
- Author:
Yan WANG
;
Yan SUN
;
Wenhai SUN
;
Zhijun CHEN
;
Fengmiao AN
- Publication Type:Journal Article
- Keywords:
glottic neoplasms;
SKP2;
MRP-1/CD9;
immunohistochemistry;
safe resection margin
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2010;(4):158-160,165
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of SKP2 and MRP-1/CD9 protein in glottic cancer and adjacent tissues,and to analyze its significance for a safe surgical margin.Method:Thirty-eight cases of glottic squamous cell carcinoma were studied for its cancer tissue, tissue 2 mm, 5 mm , and 10 mm away from cancer ,and 10 cases of vocal cord polyp were served as control. SKP2 and MRP-1/CD9 protein were examined by immunoh istochemical method.Result:The positive expression of SKP2 proteins decreased in sequence of polyp mucosa, those adjacent to carcinoma (10 mm, 5 mm, 2 mm ) and cancer tissue, and there was significant difference between them(P<0.05);On the contrary, the positive expression of the MRP-1/CD9 proteins increased in sequence of polypusmucosa, those adjacent to carcinoma (10 mm,5 mm, 2 mm) and cancer tissue,and there was significant difference between them (P<0.05).Conclusion:SKP2 and MRP-1/CD may act as the reference index for judging the biological speciality of LSCC. It is appropriate to regard 5 mm or above 5 mm away from tumors as a safe margin for surgical treatment of glottic carcinoma.
