Therapeutic effects of simvastatin on vascular endothelial cell dysfunction in patients with coronary heart disease
10.3969/j.issn.1008-0074.2013.04
- VernacularTitle:辛伐他汀对冠心病患者血管内皮细胞功能障碍的治疗作用
- Author:
Yuntao WU
;
He EN
;
Yingchun GAO
;
Yanmei CHEN
;
Lixin LIU
;
Zhenshuang CUI
;
Danyang CAO
- Publication Type:Journal Article
- Keywords:
Endothelium, vascular;
Coronary artery diseases;
Simvastatin
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2013;22(4):373-378
- CountryChina
- Language:English
-
Abstract:
Objective: To study therapeutic effects of simvastatin on vascular endothelial cell dysfunction in patients with coronary heart disease (CHD). Methods: According to LDL-C level, a total of 90 CHD patients were divided into simvastatin 20mg group (n=37, LDL-C≥2.5mmol/L), simvastatin 10mg group (n=35, 1.8mmol/L≤LDL-C<2.5mmol/L) and routine treatment group (n=18, LDL-C<1.8mmol/L). Their course of treatment was 8 weeks. Color Doppler ultrasound diagnostic instrument was used to measure flow-mediated dilation of brachial artery (FMD), and nitrate reductase method was used to measure concentration of nitric oxide (NO) in all CHD patients. Serum concentrations of TC, TG, LDL-C and HDL-C were routinely measured. Results: After treatment of eight weeks, compared with before treatment, there were significant decrease in concentrations of TC, TG and LDL-C (P<0.05 all), and significant increase in HDL-C level (P<0.05 all) in simvastatin 20mg and 10mg group, but there were no significant difference in above-mentioned all indexes between simvastatin 20mg and 10mg groups, P>0.05 all; Compared with routine treatment group, there were significant improvement in FMD [(6.01±0.49)% vs. (9.01±0.39)% vs. (9.01±0.47)%，P<0.01 all] and significant increase in serum NO concentration [(38.97±8.89)μmol/L vs. (47.67±10.89) μmol/L vs. (45.61±9.09) μmol/L，P<0.05 all] in simvastatin 20mg and 10mg group; But there were also no significant difference in serum NO and FMD between simvastatin 20mg and 10mg groups, P>0.05 all. Conclusion: Simvastatin can increase NO concentration and improve vascular endothelial cell dysfunction in CHD patients. Its mechanism may be related with lipid-lowering effect, but independent of its lipid-lowering effect
- Full text:P020130823713073248269.doc
