dBcAMP Induces Morphological Changes of Asrocytes through Epidermal Growth Factor Receptor
- VernacularTitle:dBcAMP通过上皮生长因子受体间接激活诱导星形胶质细胞形态变化
- Author:
Hongmei LI
;
Xiaolin YANG
;
Liang PENG
- Publication Type:Journal Article
- Keywords:
astrocytes;
dBcAMP;
transactivation;
epidermal growth factor receptor
- From:
Journal of China Medical University
2010;(6):404-405,409
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the signaling transduction of dBcAMP induced morphological changes of astrocytes.Methods Morphological changes of primarily cultured mouse astrocytes induced by dBcAMP were studied by immunocytochemical technique.The signaling transduction pathways underlying those changes were further explored using specific inhibitors AG1478 and GM6001.Results Zn2＋-dependent metalloproteinase and epidermal growth factor receptor（EGFR）in astrocytes were involved in the morphological changes of astrocytes induced by dBcAMP.Conclusion dBcAMP-induced transactivation pathways were delineated in the morphological changes of astrocytes.
