Clinical efficacy of comprehensive treatment in children with rhabdomyosarcoma
10.3760/cma.j.issn.1673-4408.2013.02.031
- VernacularTitle:儿童横纹肌肉瘤综合治疗疗效观察
- Author:
Yi ZHANG
;
Weiling ZHANG
;
Dongsheng HUANG
;
Fang GUO
;
Tao HAN
- Publication Type:Journal Article
- Keywords:
Rhabdomyosarcoma;
Children;
Head and neck;
Chemotherapy
- From:
International Journal of Pediatrics
2013;(2):210-213,217
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study diagnosis and treatment of rhabdomyosarcoma (RMS) in children.Method The clinical data of 43 children with RMS was retrospectively reviewed from Nov 2004 to May 2012.Their long-term survival was followed up.Forty-three children with RMS(male 26,female 17) in Beijing Tongren Hospital were enrolled.Their median age on diagnosis was 6 years old.We confirmed the diagnosis according to pathological diagnosis.Comprehensive treatment included chemotherapy,surgery and implantation of radioactive seeds,and so on.Statistical analysis was used on clinical data and treatment efficacy.Result The median follow up time of 43 cases with RMS in children was 31 mouths until May 2012.Four cases abandoned,39 cases were followed up.The cases of complete remission were 27(69％),and the cases of partly remission were 7 (18％),and the cases of dead were 5 due to cerebral metastasis.Overall survival rate was 87％ (34/39).Eight cases were treated with 125Ⅰ particles implants into its location,7 cases responded,1 case was invalid.Conclusion Although anatomic structure of RMS of head and neck was very complex,and the prognosis of it with metastatic disease was inferior,the muttidisciplinary treatment can still improve the clinical remission rate.In particular,high risk RMS with 125Ⅰ particles implants and large dose chemotherapy would be beneficial.
