The influence of trimetazidine(TMZ) on the cardiac function and neurohormonal of heart failure model in rats
10.3760/cma.j.issn.1008-6706.2013.07.006
- VernacularTitle:曲美他嗪对大鼠心力衰竭模型心功能及神经激素的影响
- Author:
Yanfen TANG
;
Xiang GAO
;
Fengli ZHANG
;
Fengrong JANG
;
Weidong JIANG
- Publication Type:Journal Article
- Keywords:
Trimetazidine;
Heart failure,congestive;
Atrial natriuretic factor;
Natriuretic peptide,C-type;
Natriuretic peptide,brain;
Angiotensins;
Rats,Sprague-Dawley
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(7):973-975,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of trimetazidine (TMZ) on the cardiac function and neurohormonal of heart failure model in rats.Methods Partially banding abdominal aortic artery to achieve congestive heart failure rats model.Interventricular septum thickness(IVST),left ventricular posterior wall thickness(LVPWT),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter (LVESD),left ventricular ejection fraction(LVEF) and shortening fraction(FS) were measured by echocardiogram,Pathological changes of myocardial cells was observed,B-type natriuretic peptide (BNP)、C-type natriuretic peptide receptor (NPRC),atrial natriuretic peptide (ANP),myosin heavy chain (β-MHC) and angiotensinl (AT1) were measured by Real-Time PCR,superoxide dismutase (SOD) was measured by immunohistochemistry method.Results Trimetazidine treatment of the high-dose group and the model group compare IVST LVPWT,LVESD,LVEDD were (0.63 ± 0.05) mn,(0.73 ± 0.06) mm,(0.73 ±0.05)mm,(0.87 ±0.06)mm and (1.07 ±0.06)mm,(1.13 ±0.06) mm,(0.93 ±0.06)mm,(1.33 ±0.06) mm,was significantly reduced (P ＜ 0.05),LVEF,FS increased to (27.75 ± 1.83) ％,(11.44 ± 0.76) ％ and (11.78 ±0.56)％,(4.27 ± 0.22)％ (P ＜ 0.01),Myocardial cell structure were remarkably improved.The expression of BNP,ANP,NPRC,ATI,β-MHC were remarkably decreased.The expression of SOD was elevated.Conclusion TMZ treatment group can improve the secretion of neurohormonal of heart failure model in rats,and also obviously improve the cardiac contractility.
