Pheochromocytoma with pancreatic islet cell tumor: a case report.
- Author:
Young Tae JU
1
;
Eun Jung JUNG
;
Sun Hoo PARK
;
Soon Chan HONG
Author Information
1. Department of Surgery, Gyeong-Sang National University College of Medicine, Korea.
- Publication Type:Case Report
- Keywords:
pheochromocytoma;
pancreatic islet cell tumor;
MEN
- MeSH:
Adenoma, Islet Cell;
Adolescent;
APUD Cells;
Ectoderm;
Female;
Humans;
Islets of Langerhans*;
Male;
Multiple Endocrine Neoplasia Type 1;
Multiple Endocrine Neoplasia Type 2a;
Neural Crest;
Pancreas;
Pheochromocytoma*;
Pyrus;
Stem Cells
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2000;4(1):191-195
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 17-years old woman with a combination of unilateral pheochromocytoma and an asymptomatic islet cell tumor of the pancreas is presented. The unusual coincidence of pheochromocytoma and pancreatic islet cell tumor in the patient is of interest as a possible crossover between MEN I and MEN II. It has been suggested that MEN I represents an abnormality of the APUD(amine precursor uptake and decarboxylation) cells of ectodermal origin. However, the possibility of a common progenitor cell in the neural crest for all APUD cells has been suggested by Pearse and Polak(1971). Recent clinical reports suggest that overlap between the two syndroms may occur. The overlapping of elements of the classical endocrine neoplasia should alert clinicians to the possibility of such associations in any particular patients. Since islet cell tumors may occur in association with pheochromocytomas and may be clinically silent, exploration of the pancreas during surgery for pheochromocytomas would seem to be useful.
