The effects of Zinc Protoporphyrin and Heme on the expression of HO-1 in cochlear and the change of auditory brainstem response on diffuse traumatic brain injury model of rats
10.3760/cma.j.issn.1008-6706.2012.22.001
- VernacularTitle:锌原卟啉与血红素对弥漫性脑外伤大鼠耳蜗血红素加氧酶表达及听性脑干反应影响的实验研究
- Author:
Xinghua FU
;
Ping ZHANG
;
Yanli DENG
;
Hexiang LU
;
Ruijun SUN
;
Ying LIU
;
Junhui ZHAO
;
Honglan GU
;
Li HAN
;
Zaixing ZHANG
- Publication Type:Journal Article
- Keywords:
Diffuse traumatic brain injury;
Zinc Protoporphyrin;
Heme;
Cochlear;
Heme oxygenase;
Auditory Brainstem Response
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;(22):3361-3364,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of Zinc Protoporphyrin and Heme on the expression of HO-1 in cochlear and the change of auditory brainstem response on diffuse traumatic brain injury model of rats.Methods Diffuse traumatic brain injury model of rats were established and randomly divided into thirteen groups.Then auditory brainstem response examination,light microscope,immunohistochemistry technique were used to evaluate the change of auditory brainstem response and the expression of HO-1 in cochlear.Results The differences of auditory brainstem response threshold and latency of wave between the experimental and the normal control group were obvious(P＜0.05).The expression of HO-1 in the control group was normal,whereas there were obvious changes of inner ear HO-1 expression in the traumatic groups.The grey value of HO-1 expression in trauma group,Znpp group and heme group was significantly associated with auditory function change(P＜0.05).Conclusion There were influence of Zinc Protoporphyrin and Hemeon the inner ear HO-1 expression and the change of auditory brainstem response with diffuse traumatic brain injury model of rats.The protective effect of heme on auditory function may be associated with the increased expression of HO-1.
