Progress of relationship between HOXB gene and leukemia
10.3760/cma.j.issn.1673-4408.2012.06.020
- VernacularTitle:HOXB基因与白血病关系的研究进展
- Author:
Feifei XIAO
- Publication Type:Journal Article
- Keywords:
HOXB;
Leukemia;
Homebox gene
- From:
International Journal of Pediatrics
2012;(6):609-611,614
- CountryChina
- Language:Chinese
-
Abstract:
HOXB gene is a homeobox gene family member and plays an important role in hematopoietic regulation.The abnormal expression is involved in leukemia.High expression of different subtypes influence leukemia progress and phenotype,and are closely related with leukemia treatment and prognosis.The higher the expression level is,the worse prognosis is.Many methods such as transgenic,inhibit of P21,combined with cytokine or MS-5 cell lines( all-trans retinoic acid) at the genetic level can reveal the pathogenesis of leukemi a and provide theoretical basis for treatment and prognosis.
