Changes of plasma glucagon level in patients with heart failure caused by coronary heart disease and its clinical significance
10.3969/j.issn.1008-0074.2013.02
- VernacularTitle:胰高血糖素在冠心病心力衰竭患者血浆中水平的变化和临床意义
- Author:
Libo WANG
;
Donghua JI
;
Xiaohui ZHAO
- Publication Type:Journal Article
- Keywords:
Glucagon;
Heart failure, congestive;
Coronary artery disease
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2013;22(2):111-113
- CountryChina
- Language:English
-
Abstract:
Objective: To investigate changes of plasma glucagon level in patients with heart failure (HF) caused by coronary heart disease (CHD) and its clinical significance. Methods: A total of 30 HF patients caused by CHD were selected as HF group, another 30 healthy subjects with corresponding age and gender were regard as normal control group. HF patients received comprehensive therapy of enhancing myocardial contractility, diuretic and vasodilator of 7~10d according to Chinese diagnostic and treatment guideline of chronic heart failure. Changes of glucagon level before and after treatment were observed. Results: Before treatment, plasma level of glucagon in HF group was significantly higher than that of normal control group [(205.67±120.22) ng/L vs. (90.53±20.5) ng/L, P<0.05]. After treatment, plasma level of glucagon [(120.42±30.33) ng/L] significantly decreased than before treatment (P<0.05) in HF group. Conclusion: Plasma glucagon significantly increases in patients with heart failure and gradually decreases to near normal level after treatment. Glucagon level may be regard as one of indexes judging patients’ condition.
- Full text:P020130514502082181401.doc
