Expression and clinicopathological significance of ADAM17 mRNA in esophageal squamous cell carcinoma

VernacularTitle:食管鳞状细胞癌组织中去整合素-金属蛋白酶17 mRNA表达的临床病理意义
Author: Hongbin LIU ; Qichang YANG ; Yi SHEN ; Yan ZHU ; Xiaojuan ZHANG ; Hao CHEN
Publication Type:Journal Article
Keywords: Esophageal neoplasms; ADAM17 mRNA; Reverse transcriprase polymerase chain reaction
From: Cancer Research and Clinic 2012;24(7):444-446,450
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the clinicopathologic significance of a disintegrin and metalloproteinase 17(ADAM 17) mRNA in esophageal squamous cell carcinoma (ESCC),and to evaluate its relation to clinicopathological features. MethodsThe expression of ADAM17 mRNA in 50 ESCC and 50 normal esophageal tissues were detected by RT-PCR. ResultsThe mRNA expression of ADAM17 in 50 ESCC and 50 normal esophageal tissues were 0.937±0.241 and 0.225±0.077,respectively.The expression of ADAM17 mRNA in the ESCC was much higher than in normal esophageal tissues (t=-19.899,P＜0.01).The expression of ADAM 17 mRNA was positively correlated with lymph node metastasis(t=-4.703,P＜0.01 ) and TNM staging (t=-2.652,P＜0.05).There were no correlation between the expression of ADAM17 mRNA and sex,age and histological grade (t=0.299,-0.907,-3.163,all P＞0.05).ConclusionADAM17 mRNA was higherly express in ESCC than in normal esophageal tissues and may play an important role in the development,invasion and metastasis of ESCC.It may be used as a prognostic factor.