Expression and clinical significance of FoxA 2 in human non-small cell lung cancer
10.3760cma.j.issn.1006-9801.2012.06.007
- VernacularTitle:FoxA2在人类非小细胞肺癌组织中的表达及其临床意义
- Author:
Weigui LUO
;
Xia HUANG
;
Feng WEI
;
Jianguo XU
;
Xuemei QIU
;
Hui SU
;
Zhongsheng WEI
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small-cell lung;
Hepatocyte nuclear factor 3-beta
- From:
Cancer Research and Clinic
2012;24(6):383-385,388
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and clinical significance of FoxA 2(hepatocyte nuclear factor 3β)in human non-small cell lung cancer(NSCLC)tissues and adjacent normal lung tissue.Methods The expressions of FoxA 2 protein in 80 cases with NSCLC tissues and adjacent normal lung tissue were tested by immunohistochemistry,the expressions of mRNA was detected by RT-PCR.Results The expressions of FoxA 2 both on protein and mRNA in NSCLC lung tissue were significantly less than those of adjacent normal lung tissue(protein expression comparison t value was 187.51,186.43,178.24 respectively;mRNA expression comparison t value was 236.70,260.13,126.27,respectively,P ＜ 0.05).However there was no difference on histopathological variability.F value equal to 1.86 and 1.69,P ＞ 0.05).In low differentiated group,the group of Ⅲ stage,with lymph node metastasis,the expression of FoxA 2 protein and mRNA was less than that in the group of high differentiated,the group of Ⅰ-Ⅱ stage,the group of non lymph node metastasis(pretein expression t values were 4.31,3.92,341,mRNA expression t values were 5.44,3.28,5.07,P＜0.05).Conclusion FoxA 2 might inhibit progression of human NSCLC.It may participate in the process of tumor tissue differentiation and lymph node metastasis in NSCLC.
