Combinations of intra-artery chemotherapy and bladder-preserving resection for primary T1G3 bladder cancer
10.3760/cma.j.issn.1006-9801.2012.05.010
- VernacularTitle:T1G3膀胱尿路上皮癌保留膀胱综合治疗的疗效评价
- Author:
Zinong TIAN
;
Duangai WEN
;
Xiaozhou HE
;
Renfang XU
;
Xianlin XU
;
Jianquan HOU
;
Jinxian PU
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Combined modality therapy;
Comparative effectiveness research
- From:
Cancer Research and Clinic
2012;24(5):316-317,327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility and effectiveness of bladder-preserving local resection combined with intra-artery chemotherapy for patients with T1G3 bladder cancer.Methods Thirty five cases with T1G3 bladder cancer were analyzed retrospectively. Patients were all treated by bladder-preserving local resection combined with intra-artery chemotherapy. Results Thirty five cases were followed up. The time of follow-up ranged from 7 to 116 months,and mean time was(66.0±18.3)months.The 5 year recurrence and bladder-preserving rate were 48.6 ％(17/35)and 68.6 ％(24/35),respectively.The overall and tumor specific survival at 5 years was 77.1％ (27/35)and 82.9 ％ (29/35).The effect of bladder-preserving local resection plus intra-artery chemotherapy was satisfactory. Moreover, intra-artery chemotherapy had no obvious side effects.Conclusion Bladder-preserving local resection combined with intra-artery chemotherapy not only can retain normal bladder function, decrease in the recurrence, but also does not reduce the survival rate. It is an effective treatment for some patients with T1G3 bladder cancer instead of cystectomy over-treatment.
