The prophylactic effects of gabapentin on postoperative sore throat after thyroid surgery.
10.4097/kjae.2013.64.2.138
- Author:
Jae Ho LEE
1
;
Hyun Kyu LEE
;
Na Hyung CHUN
;
Yoon SO
;
Chi Young LIM
Author Information
1. Department of Anesthesiology and Pain Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea. lijhmd71@hotmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Gabapentin;
Postoperative pharyngitis;
Thyroid cancer
- MeSH:
Amines;
Anesthesia;
Cyclohexanecarboxylic Acids;
Deglutition;
gamma-Aminobutyric Acid;
Humans;
Incidence;
Intubation;
Pain, Postoperative;
Pharyngitis;
Thyroid Gland;
Thyroid Neoplasms
- From:Korean Journal of Anesthesiology
2013;64(2):138-142
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Postoperative sore throat (POST) is considered a usual complication after tracheal intubation, especially, thyroid surgery. Gabapentin is a widely studied multimodal perioperative drug, which can be used to treat acute postoperative pain. The primary endpoints of this study was a reduction of the incidence of POST at rest and during the swallowing movements after thyroid surgery. And the second endpoints was a reduction of the intensity of the POST after thyroid surgery. METHODS: Seventy-one patients that underwent elective thyroid surgery received either gabapentin (Neurontin(TM) 600 mg) or placebo, orally, one hour before anesthesia. The VAS scores and incidences of POST and adverse effects were determined at 1 hr, 6 hr, 12 hr, and 24 hr after surgery at rest and during swallowing movement. RESULTS: The gabapentin group (N = 36) showed a lower incidence of POST than the placebo group (N = 35) (47% vs. 78%, P = 0.038), and had significant lower VAS score at 6 and 24 hours after surgery in the resting state. However, during the movement, no intergroup differences were found in terms of the incidence of POST (83% vs. 91%, P = 0.305) or VAS score. Furthermore, no significant difference was observed between the two groups, in adverse effects. CONCLUSIONS: Gabapentin (Neurontin(TM) 600 mg) administered 1 hr before anesthesia reduced the intensity and incidence of POST during the resting state without a significant adverse event, during the 24 hr after thyroid surgery. However, gabapentin did not reduce the intensity and incidence of POST during the swallowing movement.
