Study on the diagnostic method of microcirculation disturbance of patients with chronic hepatitis B
10.3760/cma.j.issn.1008-6706.2012.16.008
- VernacularTitle:慢性乙型肝炎肝脏微循环障碍的诊断方法研究
- Author:
Lin WANG
;
Yong MA
- Publication Type:Journal Article
- Keywords:
Hepatitis B,chronic;
Hypoxia-induciable factor;
Microcirculatory disturbance;
Sinusoidal endothelial cell
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(16):2415-2416,后插2
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the diagnostic method of microcirculation disturbance of patients with chronic hepatitis B (CHB).Methods81 patients with CHB and 5 normal volunteer were observed.Hypoxia-induciable factor was detected by immunohistochemistry stain,TXB2 and 6-Keto-PGF1α were detected by chemiluminescence and HA was detected by RIA,ultrastructure of liver was observed by transmission electron microscope (TEM).ResultsAccompany with the pathological changes of liver in patients with CHB,the strength and range of expression of HIF-1 α enhanced,HA and TXB2 of serum rised gradually( all P ＜ 0.05 ),but 6-Keto-PGF1α of blood plasma fell- off.The electron microscope showed that erythrocyte aggregation,stenosis and blockage of sinus hepaticus turned obviously,collagen fibers deposition and basal membrane formation aggravated gradually.ConclusionAssociated detec tion with HIF-1 α、HA 、TXB2 and 6-Keto-PGF1 α can reflect the condition of microcirculation of liver perfectly.
