Notch signal pathway and the pathogenesis of multiple myeloma

VernacularTitle:Notch 信号通路与多发性骨髓瘤发病机制的关系
Author: Qinqin LIU ; Dongmei GUO ; Qingliang TENG
Publication Type:Journal Article
Keywords: Multiple myeloma; Notch signal pathway
From: Journal of International Oncology 2012;39(7):544-546,560
CountryChina
Language:Chinese
Abstract: Notch signal pathway can regulate the morphogenesis,apoptosis and cellular proliferation of normal tissues and organs,which plays an important role in regulating hematopoietic cells proliferation and differentiation in bone marrow microenvironment.The occurrence and development of multiple myeloma(MM)are closely related to the bone marrow microenvironment in which many signal pathways are involved.Recent studies show that Notch signal pathway promotes the development and progression of many cancers including MM,which plays key roles in tumor invasion and drug resistance.This review focus on the recent findings on Notch signal pathway in MM,and reveals that Notch signal pathway will be identified as a potential new therapeutic target in MM.