Influence of gamma globulin to serum B cell activating factor in therapy of neonatal thrombocytopenic purpura

VernacularTitle:丙种球蛋白治疗新生儿血小板减少性紫癜对血清B细胞激活因子的影响
Author: Mei GAO ; Huasong ZENG ; Xinfang WANG ; Degen HE
Publication Type:Journal Article
Keywords: Neonatal thrombocytopenic purpura; Gamma globulin; B cell activating factor
From: International Journal of Pediatrics 2012;39(3):323-324,封3
CountryChina
Language:Chinese
Abstract: Objective To study the influence of gamma globulin to serum B cell activating factor (BAFF) in therapy of neonatal thrombocytopenic purpura.Methods Fifteen cases with neonatal thrombocytopenic purpura(treatment group) were treated with gamma globulin.Serum BAFF levels of treatment group before and after treatment and 20 healthy neonates(control group) were tested.Results Serum BAFF level of the treatment group before treatment was(0.96±0.48) μg/L,which was statistically significant compared with that of the control group[(0.48 ±0.35) μg/L](P ＜0.05).Serum BAFF level of treatment group after treatment was (0.45 ± 0.37) μg/L,which was statistically significant compared with that of before treatment (P ＜ 0.05),but was not statistically significant compared with that of the control group.Conclusion Gamma globulin can play a role in the therapy of neonatal thrombocytopenic purpura by reducing the BAFF.