The influence of pioglitazone on the expression of adiponectin in the liver of high fat diet-induced obese rats
10.3760/cma.j.issn.1008-6706.2012.11.014
- VernacularTitle:吡格列酮对高脂饲料所致肥胖大鼠肝脏组织中脂联素的影响
- Author:
Xin ZHANG
;
Jiajun YU
;
Xiulian GENG
;
Lingling WANG
;
Chuncai XUE
;
Zhonggong WANG
- Publication Type:Journal Article
- Keywords:
Adiponectin;
Insulin resistance;
Liver;
Pioglitazone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(11):1628-1629,后插1
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influence of pioglitazone on the expression of adiponectin in the liver of high fat diet-induced obese rats.Methods Forty male SD rats were randomly divided into control group which received regular diet ( n =10),high fat diet group ( n =15 ) and high fat diet goup administened pioglitazone ( n =15 ) on high fat diet.After twelve weeks,fasting blood glucose,fasting serum insulin,triglyceride,total cholesterol,and the histomorphologieal changes in liver were observed;insulin sensitivity test was performed;the fatty experimental group are treated with Pioglitazone(30mg · kg-1 · d-1,oral gavage),treatment was administered daily for 2 weeks.The control group and fatty control group all received an equal volume of vehicle (saline).The protein expression of adiponectin in the liver of rats was determined by immunohistochemistry.Results The insulin sensitive index was significantly decreased in the high-fat-diet rats compared with the control group[(0.021 ±0.010),(0.015 ±0.007),P ＜0.05] ;The protein level of adiponectin in the liver of fatty,control group was significantly decreased compared with the control group[(2929.73 ± 157.45 ),(3814.21 ±211.42),P ＜0.05],adiponectin in the liver of fatty experimental group was significantly increased compared with the fatty control group[(2929.73 ± 157.45),(3657.68 ±217.31 ),P ＜0.05].Conclusion Pioglitazone could improve the expression of adiponectin,and improve the resistance of insulin.
