Study on expression of visfatin mRNA in abdominal omental adipose tissue and its relationship with blood lipid in type 2 diabetics
10.3760/cma.j.issn.1008-1372.2012.05.O11
- VernacularTitle:内脂素在2型糖尿病伴高甘油三酯血症患者网膜脂肪组织中的表达及与血脂的关系
- Author:
Shuyan WANG
;
Xiaomei MENG
;
Shulin CHEN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2/complications/metabolism/blood;
Hypertriglyceridemia/complications/ metabolism/blood;
Omentum/metaholism;
Nicotinamide phosphoribosyltransferase/metabolism/blood
- From:
Journal of Chinese Physician
2012;14(5):615-617,621
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of visfatin mRNA in abdominal omental adipose tissue and its relationship with blood lipid in type 2 diabetes mellitus.Methods 161 type 2 diabetic patients were divided into two groups according to triglyceride ( TG ),high triglyceride group ( TG ≥ 1.7mmol/L) and normal triglyceride group(TG ＜ 1.7 mmol/L).The expression of visfatin mRNA in abdominal omental adipose tissue was measured with Northern Blot.Visfatin plasma concentration,fasting plasma glucose (FPG),blood lipid profiles and other biochemical indicators were also measured.Results Comparing with normal triglyceride group,the diabetic patients in high triglyceride group had significantly increased levels of visfatin plasma concentration [ ( 129.07 ± 21.35)ng/mL vs ( 101.65 ± 15.23 ) ng/mL,t =2.295,P ＜0.05]and mRNA expression in omental adipose tissue( P ＜0.05).Visfatin plasma concentration was positively correlated with TG( β =0.592,P ＜0.05 ) and FPG( β =0.763,P ＜0.01 ).Visfatin mRNA expression in omental adipose tissue had no correlation with FPG,TG and other biochemical indicators.Conclusions The plasma visfatin level in T2DM patients may be associated with triglyceride metabolism.
