Growth inhibition of 4T1 breast cancer cells using Au nanoparticles enhanced photosensitizer and near infrared illumination
10.3760/cma.j.issn.1673-4181.2012.03.001
- VernacularTitle:金纳米材料复合型光敏剂介导的近红外光照治疗对于4T1乳腺癌细胞生长抑制效果的实验研究
- Author:
Qing LIU
;
Xin XIE
;
Yue ZHANG
;
Fei LIU
;
Bin ZHANG
;
Jing BAI
- Publication Type:Journal Article
- Keywords:
Au nanorods;
Indocyanine green;
4Tt breast cancer cell;
Phototherapy
- From:
International Journal of Biomedical Engineering
2012;35(3):129-132,136,后插1
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the treatment efficiency of Au nanoparticles enhanced photosensitizer using near-infrared illumination.MethodsSpecific length-diameter-ratio Au Nanorods (AuNR) was coated with traditional photosensitizer indocyanine green (ICG),producing the novel photosensitizer ICG-AuNR.In order to evaluate the treatment efficiency,in-vitro near-infrared phototherapy experiments were performed on 4T1 mouse breast cancer cells.ResultsThe fluorescent intensity of ICG-AuNR is three times stronger than that of free ICG of the same concentration.Compared with free ICG of the same concentration,cell viability of 4Tl cells reduced in the near-infrared illumination treatment with the novel photosensitizer ICG-AuNR.ConclusionIn comparison with free ICG of the same concentration,the novel photosensitizer ICG-AuNR proves to be more effective on growth inhibition of cancer cells using near-infrared illumination treatment.
