Clinical study of levonorgestrel-releasing intrauterine system for adenomyosis
10.3760/cma.j.issn.1008-1372.2011.07.017
- VernacularTitle:左炔诺孕酮宫内节育系统治疗子宫腺肌病的临床研究
- Author:
Cairong CHEN
;
Yan JIN
;
Xiuqing ZHOU
;
Yibing OUYANG
;
Bifang QIN
- Publication Type:Journal Article
- Keywords:
LevonorgestreL/TU;
Intrauterine devices;
Uterine diseases/TH;
Adenomyoma/TH
- From:
Journal of Chinese Physician
2011;13(7):923-925,929
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of levonorgestrel- releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis and the influence of ovarian function. Methods Eighty patients with adenomyosis were followed up for 0, 1, 3, 6, 12 months after treating with LNG-IUS. The menstrual blood volume, dysmenorrheal, size of uteri, CA125 and EMAb level, hepatic function, serum glucose and serum lipids were observed and evaluated. Serum- levels of FSH and LH were tested before insertion and followed up for 6, 12 months after insertion, respectively. Results After inserting LNG-IUS,dysmenorrhea was obviously alleviated, and it was significantly decreased after 6 months. The menstrual blood volume was (200. 0 ±60)ml, (40. 0 ± 15)ml and (28 ±7)ml in 0, 6, 12 months after the insertion.Serum CA125 and positive rate of EMAb also significantly reduced [CA125: (50. 69 ± 10. 00) IU/L vs (18. 60 ±3.55)IU/L;EMAb:80. 0% vs 3. 8%, P ＜0. 05]. The volume of uterus reduced without significant changed (P ＞0. 05). There were little changes in the levels of hepatic function, serum glycosum, serum lipids, FSH and LH at 6 and 12 months after LNG-IUS(P ＞ 0. 05). Conclusions LUG-IUS is an effective and safe therapy for adenomyosis with dysmenorrheal and menorrhagia, and it has no significant effects on ovarian function.
