Significance of expression of HMGB1 and Smac/DIABLO protein in epithelial ovarian cancer
10.3760/cma.j.issn.1008-1372.2011.11.005
- VernacularTitle:HMGB1和Smac/DIABLO在上皮性卵巢癌中的表达及意义
- Author:
Cuixiang ZHOU
;
Jiajie WU
;
Qiao YU
;
Rixue XIE
- Publication Type:Journal Article
- Keywords:
HMGB1 protein/ME;
Mitochondrial proteins/ME;
Ovarian neoplasms/ME;
Apoptosis
- From:
Journal of Chinese Physician
2011;13(11):1455-1458,1463
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThe purpose of this study was to investigate the clinical significance of HMGB1 and Smac/DIABLO protein expression in epithelial ovarian cancer.MethodsImmunohistochemistry (IHC) and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining were used to detect the protein expression of HMGB1,Smac/DIABLO and cell apoptosis in 45 epithelial ovarian cancers by tissue microarray.ResultsThe protein expression of HMGB1 in epithelial ovarian cancers was significant higher than benign cancers and normal ovarian tissues( P ＜0.05).The protein expression of HMGB1 was related to the lymph node metastasis,which had a negative correlation with the cell apoptosis index ( rs =-0.583,P =0.000).The protein expression of Smac/DIABLO in epithelial ovarian cancers was significantly lower than benign cancers and normal ovarian tissues( P ＜0.05) ; the protein expression of HMGB1 in epithelial ovarian cancers had a negative relationship with protein expression of Smac/DIABLO( rs =-0.40,P =0.006).ConclusionsThe over-expression of HMGB1 in epithelial ovarian cancers may play an important part in the metastasis of the epithelial ovarian cancers.The over-expression of HMGB1 and the low-expression of Smac/DIABLO may take part in the occurrence and development of the epithelial ovarian cancers through abnormal cell apoptosis.
