The change and significance of heart fatty acid-binding protein and cardiac troponin Ⅰ in valve replacement patients
10.3760/cma.j.issn.1008-1372.2011.11.012
- VernacularTitle:心脏瓣膜置换围手术期H-FABP和cTnI的变化及意义
- Author:
Zhijun CHEN
;
Yonglian WANG
;
Zhongmin WANG
- Publication Type:Journal Article
- Keywords:
Heart valve prosthesis implantation;
Intraoperative period;
Myocardium/ME;
Troponin L/ME;
Fatty acid-binding proteins/ME
- From:
Journal of Chinese Physician
2011;13(11):1481-1483,1488
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore change trend of Cardiac Troponin Ⅰ (cTnI) and Heart Fatty Acid-binding Protein(H-FABP) in serum during the perioperation of valve replacement.MethodsForty patients with heumatoid valvular heart disease were selected for this study,and the patients were randomly divided into two groups.Blood samples were taken from center vein,and the serum levels of cTnI and H-FABP were determined.The change of the serum levels of these two markers at different time points was recorded and compared between two groups.ResultsThere were significant differences in the concentration of cTnl in the cold crystalloid cardioplegia group ( F between group =2744.397,P ＜0.01 ; F interaction =125.345,P ＜0.01 ).There were significant differences in the concentration of cTnI in the cold blood cardioplegia group ( F between group =1056.357,P ＜ 0.01 ; Finteraction=64.242,P ＜ 0.01 ).There were significant differences in the concentration of H - FABP in the cold crystalloid cardioplegia group ( F between group =1775.022,P ＜0.01; F interaction =34.297,P ＜0.01 ).There were significant differences in the concentration of H -FABP in the cold blood cardioplegia group ( F between group =3064.451,P ＜0.01; Finteraction=60.472,P ＜O.01 ).ConclusionsH-FABP is suitable for early diagnosis of myocardial injury because of its myocardial specificity.There are positive correlation between the peak of H-FABP and myocardial injury.There are effective and short period of window for prediction of myocardial injury caused by H-FABP.H-FABP may be served as a good myocardial injury diagnostic markers.
