Study on Macrolide resistance of mycoplasma pneumoninae
10.3760/cma.j.issn.1673-4408.2011.06.004
- VernacularTitle:肺炎支原体肺炎对大环内酯类药物耐药研究进展
- Author:
Xiaoli MA
;
Yuejie ZHENG
- Publication Type:Journal Article
- Keywords:
Mycoplasma pneumoniae;
Drug resistance;
Macrolide
- From:
International Journal of Pediatrics
2011;38(6):538-540,544
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,more and more Macrolide resistance of Mycoplasma pneumoniae becomes a hot research.The current studies suggest that the mechanisms of Macrolide resistance are drug-binding site mutations,ribosome methylation,drug efflux,and drug related fire-fighting,in which the drug target 23srRNA gene 2063,2064 mutation is significant.It has been reported that drug-resistant patients have the poor effect,including the long total febrile days and high dressing.For treatment of drug-resistant patients,most studies still use the macrolide,early use of corticosteroids may be effective.It is uncertain whether the increase in resistant strains is related with the use of macrolide.It is significant to carry out future researches in this area for clinical therapy and put off the prevalence of drug-resistant strains.
