Relationship between serum 25-hydroxyvitamin D levels and type 2 diabetes
10.3760/cma.j.issn.1008-1372.2011.09.008
- VernacularTitle:血清25-羟维生素D水平与2型糖尿病的关系
- Author:
Xiangqun DENG
- Publication Type:Journal Article
- Keywords:
Vitamin D/BL;
Diabetes mellitus,type 2/BL
- From:
Journal of Chinese Physician
2011;13(9):1181-1183,1187
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To study the relationship between serum vitamin D and type 2 diabetes.Methods By randomly stratified sampling,589 volunteers were enrolled into this study.The volunteers were classified into diabetic and non-diabetic group according to the results of fasting plasma glucose or oral glucose tolerance test.The serum 25-hydroxyvitamin D levels were detected in 249 samples.The binary logistic regression analysis was used to analyze the relationship between diabetes and its related factors.The 25-hydroxyvitamin D levels in different age stage were analyzed by Cox-Staurt trend test.The odds ratios and 95％ confidence interval of diabetes were calculated respectively according to quartiles of serum 25-hydroxyvitamin D.Results The 25-hydroxyvitamin D levels were insufficient in some extent in all age sections of volunteers.Adjusting for age,HOMA-IR,BMI,odds ratios for diabetes varied inversely across quartiles of 25-hydroxyvitamin D in a dose-dependent pattern ( r =-0.9271,P ＜0.01 ).When serum 25-hydroxyvitamin D levels were above 94.6 nmol/L,the odds ratio of diabetes was significantly reduced [OR=0.52,95％ CI (0.23 ～0.78),P ＜0.01 ].Conclusions The serum 25-hydroxyvitamin D level was negative related with type 2 diabetes.The decreased serum levels 25-hydroxyvitamin D increased onset risk of diabetes.
