Research progress of preparation and application of polyethyleneimine nanoparticles
10.3760/cma.j.issn.1673-4181.2011.04.007
- VernacularTitle:聚乙烯亚胺纳米粒制备及其应用的研究进展
- Author:
Ting LI
;
Haijie WANG
;
Yuzhen TAN
- Publication Type:Journal Article
- Keywords:
Polyethyleneimine;
Nanoparticles;
Carrier
- From:
International Journal of Biomedical Engineering
2011;34(4):218-221,226
- CountryChina
- Language:Chinese
-
Abstract:
Gene therapy has been widely explored as a promising therapeutic tool in modem medical treatment. It is one of key steps for gene therapy to choose efficient carrier. In spite of the high transfection efficiencies of viral vectors, their utilization has been impaired due to immunogenicity and safety. Nanoparticles made by chemical reaction act as non-viral vector, which solved above-mentioned problems, enhanced efficiency of gene transfection. In recent years, polyethyleneimine-based nanoparticles have become ideal carriers in the research of gene transfection, drug controlled release system and cell biology. This review focuses on properties,preparation and application of nanoparticles based on polyethyleneimine.
