Advance in the induction of islet-like cell from bone marrow mesenchymal stem cells through gene transfection
10.3760/cma.j.issn.1673-4181.2011.04.010
- VernacularTitle:通过基因转染诱导骨髓间充质干细胞为胰岛样细胞的进展
- Author:
Sheng BAI
;
Mingwei SHENG
;
Xiaomian LI
- Publication Type:Journal Article
- Keywords:
Gene transfection;
Bone marrow mesenchymal stem cells;
Islet-like cell;
Diabetes
- From:
International Journal of Biomedical Engineering
2011;34(4):232-234,239
- CountryChina
- Language:Chinese
-
Abstract:
As the progress of organ and tissue transplantation technology, pancreas and islet transplantation has been introduced to treat diabetes and became hot. However, many shortcomings and re-lated issues need to be improved concerning the islet cell sources. Bone marrow mesenchymal stem cells (BMSCs) has become the hot topic on induction of islet-like cell because it was simple to access, easy to culture and possess the function of immunosuppressian. In recent years, artificial construction of pancreatic islet cells, which uses gene recombinant and gene transfection to reforge islet-like cells, has improved the induction rate of BMSCs and increased the amount of insulin serection, and it also provide new ideas and direction for the treatment of diabetes.
