Expression and significance of TREM-1 gene in mice with severe acute pancreatitis

VernacularTitle:TREM-1基因在重症急性胰腺炎大鼠中的表达及意义
Author: Changyou WANG ; Peng ZHAO ; Guozhi ZHANG ; Wenbin CAO ; Xiaotao WANG ; Yongkui ZHAO ; Bo ZHANG ; Mingxin CUI ; Yang LIU
Publication Type:Journal Article
Keywords: Triggering receptor expressed on myeloid cells; Severe acute pancreatitis; Tumor necrosis factor-alpha
From: International Journal of Surgery 2012;39(10):662-665,封3
CountryChina
Language:Chinese
Abstract: Objective Through detecting the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in pancreas and lung of rats with severe acute panereatitis,to approach the role of TREM-1 in severe actute pancreatitis pathogenesis,and provid a new molecular target for SAP.Methods Thirty healthy male Wistar rat were randomly divided into two groups:control group(group A),n =15 ; severe acute pancreatitis group (group B),n =15.The model of severe acute pancreatitis of rats was induced by retrograde injection of 5％ sodium taurocholate into the pancreatic duct.Results TREM-1 in pancreatic tissues and lung tissues was significantly higher in group B than group A in three time points(6 h,12 h,24 h) and had significant changes(P ＜ 0.05),and had a positive correlation with pancreatic pathology.Conclusion TREM-1 was significantly expressed in severe acute pancreatitis,and aggravated pancreas damage and systemic inflammatory response syndrome.