Docetaxel-loaded PCL-Tween 80 nanoparticles for glioma chemotherapy

VernacularTitle:聚己内酯-吐温80共聚物纳米粒在神经胶质瘤化疗中的应用
Author: Lei XU ; Liqin JIANG ; Hongfan SUN ; Chao ZHANG ; Hai WANG ; Yan TIAN ; Yi ZHENG ; Hongbo CHEN ; Lin MEI ; Kexin LIU
Publication Type:Journal Article
Keywords: Polycaprolactone-Tween 80; Glioma; Docetaxel; Nanoparticles
From: International Journal of Biomedical Engineering 2012;35(4):193-196,229,后插1
CountryChina
Language:Chinese
Abstract: Objective To investigate the feasibility of using a novel docetaxel-loaded polycaprolactoneTween 80 (PCL-Tween 80) nanoparticles for glioma therapy.Methods Two types of docetaxel-loaded nanoparticles were made from commercial polycaprolactone (PCL) and a self-synthesized PCL-Tween 80 copolymer using a modified solvent extraction/evaporation method.A C6 glioma cell line was used to investigate the uptake of polymeric nanoparticles by brain cancer cells.In vitro cancer cell viability was assessed using MTT toxic assay.Results The nanoparticles were found by FESEM to have a spherical shape and be around 200 nm in diameter.The copolymers could encapsulate 10% of the drug in the nanoparticles and release 34.9% of the encapsulated drug over 28 days.The drug-loaded PCL-Tween 80 nanoparticles showed better in vitro cytotoxicity towards C6 cancer cells than Taxotere at the same drug concentration.Conclusion Nanoparticles using PCL-Tween 80 copolymer as drug delivery vehicles may have a promising outcome for glioma patients.