Low expression of cystic fibrosis transmembrane conductance regulator gene allele IVS8-5T may be associated with decreased prostate cancer risk

VernacularTitle:囊性纤维化跨膜电导调节子基因IVS8-5T与前列腺癌低风险的相关性研究
Author: Di QIAO ; Lixin HUA ; Long YI ; Ligang NI ; Yi DING ; Shige ZHANG ; Ye WU ; Jiulin WANG ; Hongfei WU
Publication Type:Journal Article
Keywords: Prostate neoplasms; CFTR; Polymorphism
From: Cancer Research and Clinic 2012;24(8):515-517,523
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between functional polymorphism IVS8-poly (T) in cystic fibrosis transmembrane conductance regulator (CFTR) gene and prostate cancer risk.Methods A population-based case-control study was conducted including 230 prostate cancer patients and 230 agematched controls.PCR-STRP was used to analysis the IVS8-poly (T) tract in CFTR gene.Results The prevalences of the low expression allele,the IVS8-5T,in prostate cancer patients and controls were 1.52 ％ (7/460) and 5.22 ％ (24/460),respectively (x2 =12.489,P =0.002).Logistic regression analysis confirmed the 5T/7T genotype was in protective association with prostate cancer risk (OR =0.232,P =0.003,95 ％ CI0.090-0.599).Conclusion The low expression CFTR IVS8-5T allele contributes to a reduced risk of prostate cancer in Chinese Han population,and may be a protective factor against prostate cancer.