Comparafive study on arterial blood gas analysis and pulmonary functions of emphysematous rabbits after unilateral and bilateral lung volume reduction surgery
10.3760/cma.j.issn.1001-4497.2011.09.015
- VernacularTitle:单侧、双侧肺减容术后肺气肿兔动脉血气与肺通气功能的变化
- Author:
Qunyou TAN
;
Bo DENG
;
Dongliang LI
;
Taiqian GONG
;
Shaolin TAO
;
Ruwen WANG
;
Yaoguang JIANG
- Publication Type:Journal Article
- Keywords:
Emphysema;
obstructive Pneumonectomy Arterial blood gas analysis Pulmonary functions Rabbit
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2011;27(9):561-563,565
- CountryChina
- Language:Chinese
-
Abstract:
Objective Describes the changes of arterial blood gas analysis and pulmonary functions of emphysematous rabbits after unilateral and bilateral lung volume reduction surgery.Methods Sixty rabbits were randomly and equally divided into 6 groups:control group(A),emphysema group( B),unilateral sham operation group(C),unilateral lung volume reduction surgery group( D),bilateral sham operation group( E ) and bilateral lung volume reduction surgery group(F).Obstructive emphysema was induced with somg and papain in tie rabbits of the remaining groups except the control one.Eight weeks later,arterial blood gas analysis and pulmonary functions were detected.Results Compared with group B,pH,PaO2,PaCO2,SaO2,forced expirratory volume in 0.5 s,froced expiratory capacity,functional residual capacity,total lung capacity,dynamic compliance,and resistance in expiartory phase could be improved in group D ( P ＜ 0.05 ).The amelioration of those results were more obvious in group F ( P ＜0.05).Two rabbits in group F died after opertation.Conclusion Bilateral lung volume reduction surgery could more markedly improve the arterial blood gas analysis and pulmonary functions of emphysematous rabbits than unilateral operation.
