Expression and signifance of Survivin and Bcl-2 in human ampullary carcinoma
10.3760/cma.j.issn.1673-4203.2012.05.008
- VernacularTitle:Survivin、Bcl-2在壶腹癌组织中的表达及临床意义
- Author:
Dong XUE
;
Tongjun ZHANG
;
Xinjun LI
;
Bengang GONG
;
Xiuliang XIA
;
Yuxin CHEN
- Publication Type:Journal Article
- Keywords:
Carcinoma of the ampulla of Vater;
Survivin;
Bcl-2;
Immunohischemistry
- From:
International Journal of Surgery
2012;39(5):309-313,封3
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the expressions of Survivin and Bcl-2 in carcinoma of the ampulla of Vater and their clinical significance.Methods The expressions of Survivin and Bcl-2 proteins were tested by EnVision immunohistochemistry in 40 cases of ampullary carcinomas,and 8 cases of normal ampulla of rater as control.ResultsThe positive expression of Survivin and Bcl-2 in the tissues from the ampullary carcinoma was significantly higher than that in the normal controls(82.5％,72.5％ vs 0％,12.5％,P ＜0.05).The expression of Survivin and Bcl-2 had no relations with the sex,age,tumor size,histological types,and clinical stages( P ＞ 0.05 ).The differences of the expression of Survivin and Bcl-2 in ampullary carcinoma of duodenal invasion,pancreatic invasion,and lymph node metastasis were significant(P ＜ 0.05) ; Significantly positive correlation was found between the expression of Survivin and Bcl-2 by using spearman correlation analysis( r =0.647,P ＜ 0.05 ).Conclusions Survivin and Bcl-2 may play an important role in tumorigenesis of ampullary carcinoma.Combined detection of Survivin and Bcl-2 may be useful to determine the degree of malignancy and the progress of the ampullary carcinoma.
