Aminopeptidase N and its inhibitors and carcinoma
10.3760/cma.j.issn.1673-422X.2012.03.003
- VernacularTitle:氨肽酶N及其抑制剂与肿瘤
- Author:
Keling PEI
;
Houli ZHANG
;
Shuxiang CUI
- Publication Type:Journal Article
- Keywords:
Antigens,CD13;
Neoplasm invasiveness;
Neoplasm metastasis
- From:
Journal of International Oncology
2012;39(3):169-171,233
- CountryChina
- Language:Chinese
-
Abstract:
Aminopeptidase N,a zinc-dependent exopeptidase,is highly expressed in many kinds of tumors,which involves in the degradation of extracellular matrix barriers and angiogenesis and promotes the invasion and metastasis of cancer cells.Aminopeptidase N inhibitors can induce apoptosis and inhibit the invasion and metastasis of tumor cells,which has become an attractive target for anti-tumor therapy.
