Prognostic factors of acute exacerbation of chronic obstructive pulmonary disease
10.3760/cma.j.issn.1008-1372.2011.12.008
- VernacularTitle:慢性阻塞性肺疾病急性加重患者的预后影响因素
- Author:
Zhiqiang LV
;
Yun CHEN
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Prognosis
- From:
Journal of Chinese Physician
2011;13(12):1611-1614,1620
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate prognostic factors in acute exacerbation of COPD (AECOPD).Methods352 AECOPD patients were investigated.26 possible variables were analyzed.Multivariate Logistic and Cox proportional-hazards regression analysis were used.ResultsAccording to multivariate Logistic regression,it showed seven factors were statistically significant for short term prognosis ( P <0.05 ),including PaO2 ( OR =0.082),CKMB ( OR =4.967 ),mechanical ventilation ( OR =6.903 ),albumin ( OR =0.221 ),FEV1% ( OR =0.255 ),charlson index ( OR =8.406 ) and hospital day ( OR =0.075).According to multivariate Cox regression,it showed seven factors were statistically significant for long term survival ( P < 0.05 ) including acute exacerbation frequency( HR =1.611 ),charlson index( HR =4.319),SaO2 ( HR =0.224 ),troponin Ⅰ ( HR =3.824 ),albumin ( HR =0.569 ),hospital day ( HR =0.456) and FEV1% (HR =0.494).Acute exacerbation frequency was correlated with dyspnea scale( rs =0.508,P < 0.01 ).ConclusionsPaO2,albumin,FEV1%,CKMB and charlson index were related with short term prognosis.SaO2,albumin,FEV1 %,troponin Ⅰ,charlson index and acute exacerbation frequency were related with long term survival.Higher acute exacerbation frequency contributed to more severe breathing difficulties and worse quality of life.