Expression of pancreatic Kir6.2 in diabetes rats and the intervention of astragalus polysaccharide at different doses
10.3760/cma.j.issn.1673-4203.2011.06.006
- VernacularTitle:不同剂量的黄芪多糖对糖尿病大鼠胰腺Kir.6.2表达的干预研究
- Author:
Baoying WU
;
Chongxu WU
;
Chengrui XUE
- Publication Type:Journal Article
- Keywords:
Diabetes;
Kir6.2;
Astragalus polysaccharide;
Expression
- From:
International Journal of Surgery
2011;38(6):376-379,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of astragalus polysaccharide administration on the the expression of pancreatic Kir6.2 in diabetes rats.Methods Wistar rats were induced diabetes mellitus,then divided into model group,control group,low dose group,and high dose group randomly.After OGTT of them were observed,determination of the Kir6.2 mRNA and protein expression levels in pancreas was performed by RT-PCR and Western blotting.Results The expression of Kir6.2 in model group decreased significantly,and the expressions of Kir6.2 in low dose and hish dose groups were higher than the model group (P<0.05).Conclusion Astragalus polysaccharide displayed up-regulation to the expression of pancreatic Kir6.2.which may be a mechanism on reducing blood glucose.
